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ChemInform Abstract: First Efficient Uncharged Reactivators for the Dephosphylation of Poisoned Human Acetylcholinesterase.

✍ Scribed by Guillaume Mercey; Tristan Verdelet; Geraldine Saint-Andre; Emilie Gillon; Alain Wagner; Rachid Baati; Ludovic Jean; Florian Nachon; Pierre-Yves Renard

Book ID: 102064227
Publisher: John Wiley and Sons
Year: 2011
Weight: 22 KB
Volume: 42
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201135204

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✦ Synopsis

Abstract

The title compounds (I) are extremely promising uncharged reactivators for poisoned human AChE with a superior or similar in vitro ability to reactivate the enzyme as that of HI‐6, obidoxime, TMB‐4 and HL‐7.

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## Abstract A variety of (het)aryl aldoximes, (het)arylamidoximes and hydroxamic acids, e.g. (I), is tested as nucleophilic agent for the hydrolysis of phenylphosphonothioate (PhX), a member of a class of organophosphorus used as chemical warfare agents.