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Phenyltetrahydroisoquinoline–Pyridinaldoxime Conjugates as Efficient Uncharged Reactivators for the Dephosphylation of Inhibited Human Acetylcholinesterase

✍ Scribed by Mercey, Guillaume; Renou, Julien; Verdelet, Tristan; Kliachyna, Maria; Baati, Rachid; Gillon, Emilie; Arboléas, Mélanie; Loiodice, Mélanie; Nachon, Florian; Jean, Ludovic; Renard, Pierre-Yves

Book ID: 118171795
Publisher: American Chemical Society
Year: 2012
Tongue: English
Weight: 288 KB
Volume: 55
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm3015519

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## Abstract The title compounds (I) are extremely promising uncharged reactivators for poisoned human AChE with a superior or similar in vitro ability to reactivate the enzyme as that of HI‐6, obidoxime, TMB‐4 and HL‐7.