✦ LIBER ✦

ChemInform Abstract: Design, Synthesis and Evaluation of New α-Nucleophiles for the Hydrolysis of Organophosphorus Nerve Agents: Application to the Reactivation of Phosphorylated Acetylcholinesterase.

✍ Scribed by Geraldine Saint-Andre; Maria Kliachyna; Sanjeevarao Kodepelly; Ludivine Louise-Leriche; Emilie Gillon; Pierre-Yves Renard; Florian Nachon; Rachid Baati; Alain Wagner

Publisher: John Wiley and Sons
Year: 2011
Weight: 24 KB
Volume: 42
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201152199

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✦ Synopsis

Abstract

A variety of (het)aryl aldoximes, (het)arylamidoximes and hydroxamic acids, e.g. (I), is tested as nucleophilic agent for the hydrolysis of phenylphosphonothioate (PhX), a member of a class of organophosphorus used as chemical warfare agents.

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