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ChemInform Abstract: Dual-Acting Agents with α1-Adrenoceptor Antagonistic and Steroid 5α-Reductase Inhibitory Activities. Synthesis and Evaluation of Arylpiperazine Derivatives.

✍ Scribed by Hiroki Sato; Osamu Kitagawa; Yoshiyuki Aida; Jun Chikazawa; Tadashi Kurimoto; Mineo Takei; Yoshihisa Fukuta; Kiyoshi Yoshida


Publisher
John Wiley and Sons
Year
2010
Weight
39 KB
Volume
30
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Synthesis and 5α-Re
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Synthesis and 5α-Reductase Inhibitory Activities of Benzofuran Derivatives with a Carbamoyl Group. -5-Carbamoyl (VII) and 6-carbamoyl derivatives (XI) are prepared and found to show inhibitory activity of human 5α-reductase. The key step furan ring cyclization occurs by using HCl, cf. product (V),