ChemInform Abstract: A Convenient Synthesis of 2-Phenylbenzofuran Derivatives with Potent Testosterone 5α-Reductase Inhibitory Activities.
✍ Scribed by Koki Ishibashi; Katsuyoshi Nakajima; Takahide Nishi
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 35 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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Synthesis and 5α-Reductase Inhibitory Activities of Benzofuran Derivatives with a Carbamoyl Group. -5-Carbamoyl (VII) and 6-carbamoyl derivatives (XI) are prepared and found to show inhibitory activity of human 5α-reductase. The key step furan ring cyclization occurs by using HCl, cf. product (V),
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