ChemInform Abstract: The Asymmetric Synt
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Feng Liu; Wansheng Yu; Wenhua Ou; Xiaoke Wang; Libo Ruan; Yiming Li; Xijiang Pen
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Article
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2010
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John Wiley and Sons
β 23 KB
## Abstract Key step in the improved synthetic pathway to sitagliptin (VII), a new DPPβIV inhibitor for the treatment of type 2 diabetes mellitus, is an asymmetric Michael addition to give intermediate (IV).