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ChemInform Abstract: Conformationally Constrained NO Synthase Inhibitors: Rigid Analogues of L-N-Iminoethylornithine.

โœ Scribed by Eustache; Jacques Eustache; Jacques; Alfred Grob; Charles Lam; Odile Sellier; Gerhard Schulz

Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
30
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

Conformationally Constrained NO Synthase Inhibitors: Rigid Analogues of L-N-Iminoethylornithine.

-Three series of type (VI), (XI), and (XII) are prepared with the aim to create novel nitric oxide synthase inhibitors. Derivatives of type (VI) show desired activity. The most potent derivatives are found to be compounds of type (XI). In the third series only compound (XII) found to be active.

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