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ChemInform Abstract: Conformationally Constrained Analogues of Endogenous Tripeptide Inhibitors of Zinc Metalloproteinases.

โœ Scribed by Silvana D'Alessio; Carlo Gallina; Enrico Gavuzzo; Cesare Giordano; Barbara Gorini; Fernando Mazza; Mario Paglialunga Paradisi; Gabriella Panini; Giorgio Pochetti

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
32
Category
Article
ISSN
0931-7597

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Conformationally Constrained NO Synthase Inhibitors: Rigid Analogues of L-N-Iminoethylornithine. -Three series of type (VI), (XI), and (XII) are prepared with the aim to create novel nitric oxide synthase inhibitors. Derivatives of type (VI) show desired activity. The most potent derivatives are fo