ChemInform Abstract: Chiral Acetylenic Sulfoxide in Enantioselective Synthesis of Yohimbine Alkaloid.

✍ Scribed by A. W. M. LEE; W. H. CHAN; T. MO

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 27 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199732186

✦ Synopsis

Chiral Acetylenic Sulfoxide in Enantioselective Synthesis of Yohimbine Alkaloid. -Michael addition of the secondary amine (I) to the chiral acetylenenic sulfoxide (II) followed by acid induced cyclization affords (III) as major product. It is a precursor of optically pure (IV), a known synthon of pentacyclic yohimbine alkaloids. -(LEE, A.