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ChemInform Abstract: ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. Design and Synthesis of 2-Substituted Butanedioic Acids as Novel, Potent Inhibitors of the Enzyme.

โœ Scribed by A. D. GRIBBLE; R. E. DOLLE; A. SHAW; D. MCNAIR; R. NOVELLI; C. E. NOVELLI; B. P. SLINGSBY; V. P. SHAH; D. TEW; B. A. SAXTY; M. ALLEN; P. H. GROOT; N. PEARCE; J. YATES

Book ID
112042004
Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
27
Category
Article
ISSN
0931-7597

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ChemInform Abstract: ATP-Citrate Lyase a
ChemInform Abstract: ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. Part 2. Synthesis and Evaluation of (3R*,5S*)-ฯ‰-Substituted-3-carboxy-3,5-dihydroxyalkanoic Acids and Their ฮณ-Lactone Prodrugs as Inhibitors of the Enzyme in vitro and in vivo.
โœ A. D. GRIBBLE; ET AL. ET AL. ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 34 KB ๐Ÿ‘ 2 views

ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. Part 2. Synthesis and Evaluation of (3R\*,5S\*)-ฯ‰-Substituted-3carboxy-3,5-dihydroxyalkanoic Acids and Their ฮณ-Lactone Prodrugs as Inhibitors of the Enzyme in vitro and in vivo. -A series of the title compounds is synthesized and evalua