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ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. 2. Synthesis and Evaluation of (3 R ,5 S )-ω-Substituted-3-carboxy-3,5-dihydroxyalkanoic Acids and Their γ-Lactone Prodrugs as Inhibitors of the Enzyme in Vitro and in Vivo

✍ Scribed by Gribble, Andrew D.; Ife, Robert J.; Shaw, Antony; McNair, David; Novelli, Christine E.; Bakewell, Susan; Shah, Virendra P.; Dolle, Roland E.; Groot, Pieter H.; Pearce, Nigel; Yates, John; Tew, David; Boyd, Helen; Ashman, Stephen; Eggleston, Drake S.; Haltiwanger, R. Curtis; Okafo, George

Book ID: 119952307
Publisher: American Chemical Society
Year: 1998
Tongue: English
Weight: 275 KB
Volume: 41
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm980091z

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ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. Part 2. Synthesis and Evaluation of (3R\*,5S\*)-ω-Substituted-3carboxy-3,5-dihydroxyalkanoic Acids and Their γ-Lactone Prodrugs as Inhibitors of the Enzyme in vitro and in vivo. -A series of the title compounds is synthesized and evalua

ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. 2. Synthesis and Evaluation of (3 R *,5 S *)-ω-Substituted-3-carboxy-3,5-dihydroxyalkanoic Acids and Their γ-Lactone Prodrugs as Inhibitors of the Enzyme in Vitro and in Vivo

ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. 2. Synthesis and Evaluation of (3 R ,5 S )-ω-Substituted-3-carboxy-3,5-dihydroxyalkanoic Acids and Their γ-Lactone Prodrugs as Inhibitors of the Enzyme in Vitro and in Vivo