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ChemInform Abstract: ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. Part 2. Synthesis and Evaluation of (3R,5S)-ω-Substituted-3-carboxy-3,5-dihydroxyalkanoic Acids and Their γ-Lactone Prodrugs as Inhibitors of the Enzyme in vitro and in vivo.

✍ Scribed by A. D. GRIBBLE; ET AL. ET AL.

Publisher: John Wiley and Sons
Year: 2010
Weight: 34 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199903116

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✦ Synopsis

ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. Part 2.

Synthesis and Evaluation of (3R*,5S*)-ω-Substituted-3carboxy-3,5-dihydroxyalkanoic Acids and Their γ-Lactone Prodrugs as Inhibitors of the Enzyme in vitro and in vivo.

-A series of the title compounds is synthesized and evaluated as inhibitors of ATP-citrate lyase. The most active compound (III) is able to induce hypocholesterolemic and hypotriglyceridemic effects in rat and dog. -(GRIBBLE, A. D.

ChemInform Abstract: ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. Part 2. Synthesis and Evaluation of (3R*,5S*)-ω-Substituted-3-carboxy-3,5-dihydroxyalkanoic Acids and Their γ-Lactone Prodrugs as Inhibitors of the Enzyme in vitro and in vivo.

✦ Synopsis

ChemInform Abstract: ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. Part 2. Synthesis and Evaluation of (3R,5S)-ω-Substituted-3-carboxy-3,5-dihydroxyalkanoic Acids and Their γ-Lactone Prodrugs as Inhibitors of the Enzyme in vitro and in vivo.