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ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. Design and Synthesis of 2-Substituted Butanedioic Acids as Novel, Potent Inhibitors of the Enzyme

โœ Scribed by Gribble, Andrew D.; Dolle, Roland E.; Shaw, Antony; McNair, David; Novelli, Riccardo; Novelli, Christine E.; Slingsby, Brian P.; Shah, Virendra P.; Tew, David; Saxty, Barbara A.; Allen, Mark; Groot, Pieter H.; Pearce, Nigel; Yates, John


Book ID
120178925
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
832 KB
Volume
39
Category
Article
ISSN
0022-2623

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ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. Part 2. Synthesis and Evaluation of (3R\*,5S\*)-ฯ‰-Substituted-3carboxy-3,5-dihydroxyalkanoic Acids and Their ฮณ-Lactone Prodrugs as Inhibitors of the Enzyme in vitro and in vivo. -A series of the title compounds is synthesized and evalua