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ChemInform Abstract: Asymmetric Syntheses of (-)-Aphanorphine and (-)-Eptazocine.

โœ Scribed by M. NODE; H. IMAZATO; R. KUROSAKI; Y. KAWANO; T. INOUE; K. NISHIDE; K. FUJI


Book ID
112031871
Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
27
Category
Article
ISSN
0931-7597

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๐Ÿ“œ SIMILAR VOLUMES


ChemInform Abstract: Enzymatic Asymmetri
โœ A. FADEL; P. ARZEL ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 35 KB

Enzymatic Asymmetrization of Prochiral ฮฑ,ฮฑ-Disubstituted-malonates and -1,3-propanediols: Formal Asymmetric Syntheses of (-)-Aphanorphine and (+)-Eptazocine. -A method for the synthesis of the title compounds (X) and (XIII) is presented with a view to their analgesic activity. Two key intermediates

An efficient asymmetric synthesis of key
โœ Stephen K. Taylor; Milica Ivanovic; Lloyd J. Simons; Matthew M. Davis ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 190 KB

Efficient, formal syntheses of aphanorphine and eptazocine are reported that involve epoxide cyclizations. The necessary chiral epoxides were prepared following treatment of diols prepared by Sharpless asymmetric osmylations of an alkene. The cyclizations formed a ring compound with the same enantio