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ChemInform Abstract: Enzymatic Asymmetrization of Prochiral α,α-Disubstituted- malonates and -1,3-propanediols: Formal Asymmetric Syntheses of (-)- Aphanorphine and (+)-Eptazocine.

✍ Scribed by A. FADEL; P. ARZEL

Book ID
101847694
Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis

Enzymatic Asymmetrization of Prochiral α,α-Disubstituted-malonates and -1,3-propanediols: Formal Asymmetric Syntheses of (-)-Aphanorphine and (+)-Eptazocine.

-A method for the synthesis of the title compounds (X) and (XIII) is presented with a view to their analgesic activity. Two key intermediates, e.g. (VII), are prepared by enzymatic asymmetrization of prochiral malonates, e.g. (I). -(FADEL, A.

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