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ChemInform Abstract: A Stereospecific Synthesis of 1,2-Disubstituted Homopropargylic Protected Alcohols from Bromoallenols.

โœ Scribed by Nicolas Bernard; Fabrice Chemla; Jean F. Normant

Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
30
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

A Stereospecific Synthesis of 1,2-Disubstituted Homopropargylic Protected Alcohols from Bromoallenols.

-Bromoallenols [cf. (I)] or the related ethers [cf. (V)] undergo a stereospecific reaction with organocopper or Grignard reagents providing 1,2-disubstituted derivatives (III) and (VII).

๐Ÿ“œ SIMILAR VOLUMES

A New Diastereodivergent Synthesis of 1,
A New Diastereodivergent Synthesis of 1,2-Disubstituted Homopropargylic Alcohols
โœ Fabrice Chemla; Nicolas Bernard; Jean Normant ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 349 KB ๐Ÿ‘ 1 views

Disubstituted homopropargylic alcohols can be prepared inversion through the intermediate formation of a bromoallenol moiety. in a diastereodivergent fashion starting from propargylic epoxides by BF 3 -catalysed direct ring-opening or by double served. Thus disubstituted anti homopropargylic alcohol