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ChemInform Abstract: A Formal Synthesis of (-)-α-Kainic Acid.

✍ Scribed by J. COSSY; M. CASES; D. GOMEZ PARDO

Publisher
John Wiley and Sons
Year
2010
Weight
42 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

A Formal Synthesis of (-)-α-Kainic Acid.

-Starting from Lpyroglutamic acid (-)-(I), the known precursor (-)-(XVI) for the synthesis of the title compound is presented. The key step in this approach is the SmI 2 -mediated ketyl radical cyclization of the enecarbamate (X). Under irradiation conditions this cyclization fails.

-(COSSY,

📜 SIMILAR VOLUMES

ChemInform Abstract: Stereoselective Syn
ChemInform Abstract: Stereoselective Synthesis of (.+-.)-α-Kainic Acid Using Free Radical Key Reactions.
✍ M. D. BACHI; N. BAR-NER; A. MELMAN 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 38 KB 👁 1 views

Stereoselective Synthesis of (±)-α-Kainic Acid Using Free Radical Key Reactions. -The title compound (XI) is obtained via two routes from the highly substituted isocyanide and the isothiocyanate (XII) via the common intermediate (IX). In both routes the key synthons (cf. (IV) and (XIV)) are obtained