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ChemInform Abstract: A Convergent Approach to (R)-Tiagabine by a Regio- and Stereocontrolled Hydroiodination of Alkynes.

โœ Scribed by Giuseppe Bartoli; Roberto Cipolletti; Giustino Di Antonio; Riccardo Giovannini; Silvia Lanari; Mauro Marcolini; Enrico Marcantoni

Publisher
John Wiley and Sons
Year
2010
Weight
47 KB
Volume
41
Category
Article
ISSN
0931-7597

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ChemInform Abstract: A Convergent Approa
ChemInform Abstract: A Convergent Approach to Functionalized Alkynes.
โœ J. BOIVIN; S. HUPPE; S. Z. ZARD ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 34 KB ๐Ÿ‘ 1 views

The convergent approach to a broad variety of functionalized alkynes starts with a Knoevenagel-type condensation of 4-unsubstituted isoxazolines with ketones or aldehydes. The resulting adducts are subjected to Michael addition with various nucleophiles such as hydride, cyanide or phosphite. Exposur