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ChemInform Abstract: 4,5-Dihydro-3-(2-pyrazinyl)naphtho(1,2-c)pyrazole: A Potent and Selective Inhibitor of Steroid-17α-Hydroxylase-C17,20-Lyase ( P450 17).

✍ Scribed by R. W. HARTMANN; G. A. WAECHTER; T. SERGEJEW; R. WUERTZ; J. DUEERKOP


Book ID
112024181
Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
26
Category
Article
ISSN
0931-7597

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## Abstract The synthesis and biological evaluation of __Z__‐ and __E__‐1‐methyl‐2‐(1‐hydroximinoethyl)‐6‐methoxy‐3,4‐dihydro‐naphthalene (__Z__‐1 and __E__‐1) as nonsteroidal inhibitors of 17α‐hydroxylase‐C17,20‐lyase (P450 17, CYP17) is described. __Z__‐1 and __E__‐1 were separated by column chro