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Synthesis and Evaluation of Azole-substituted 2-Aryl-6-methoxy-3,4-dihydronaphthalenes and -naphthalenes as Inhibitors of 17α-Hydroxylase-C17,20-Lyase (P450 17

✍ Scribed by Yan Zhuang; Rolf W. Hartmann


Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
123 KB
Volume
332
Category
Article
ISSN
0365-6233

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## Abstract The synthesis and biological evaluation of __Z__‐ and __E__‐1‐methyl‐2‐(1‐hydroximinoethyl)‐6‐methoxy‐3,4‐dihydro‐naphthalene (__Z__‐1 and __E__‐1) as nonsteroidal inhibitors of 17α‐hydroxylase‐C17,20‐lyase (P450 17, CYP17) is described. __Z__‐1 and __E__‐1 were separated by column chro