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ChemInform Abstract: Synthesis of Z- and E-1-Methyl-2-(1-hydroximinoethyl)-6-methoxy-3,4-dihydronaphthalene and Evaluation as Inhibitors of 17α-Hydroxylase-C17,20-lyase (P450 17).

✍ Scribed by Y. ZHUANG; J. ZAPP; R. W. HARTMANN

Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
29
Category
Article
ISSN
0931-7597

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Synthesis of Z- and E-1-Methyl-2-(1-hydr
Synthesis of Z- and E-1-Methyl-2-(1-hydroximinoethyl)-6-methoxy-3,4-dihydronaphthalene and Evaluation as Inhibitors of 17α-Hydroxylase-C17,20-Lyase (P450 17)
✍ Yan Zhuang; Josef Zapp; Rolf W. Hartmann 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 247 KB 👁 2 views

## Abstract The synthesis and biological evaluation of __Z__‐ and __E__‐1‐methyl‐2‐(1‐hydroximinoethyl)‐6‐methoxy‐3,4‐dihydro‐naphthalene (__Z__‐1 and __E__‐1) as nonsteroidal inhibitors of 17α‐hydroxylase‐C17,20‐lyase (P450 17, CYP17) is described. __Z__‐1 and __E__‐1 were separated by column chro