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ChemInform Abstract: Synthesis and Evaluation of Azole-Substituted 2-Aryl-6-methoxy-3,4-dihydronaphthalenes and -naphthalenes as Inhibitors of 17α-Hydroxylase-C17,20-lyase (P450 17).

✍ Scribed by Yan Zhuang; Rolf W. Hartman

Publisher
John Wiley and Sons
Year
2010
Weight
37 KB
Volume
30
Category
Article
ISSN
0931-7597

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✍ Yan Zhuang; Josef Zapp; Rolf W. Hartmann 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 247 KB 👁 2 views

## Abstract The synthesis and biological evaluation of __Z__‐ and __E__‐1‐methyl‐2‐(1‐hydroximinoethyl)‐6‐methoxy‐3,4‐dihydro‐naphthalene (__Z__‐1 and __E__‐1) as nonsteroidal inhibitors of 17α‐hydroxylase‐C17,20‐lyase (P450 17, CYP17) is described. __Z__‐1 and __E__‐1 were separated by column chro