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CHEK2 variants associate with hereditary prostate cancer

✍ Scribed by Seppälä, E H; Ikonen, T; Mononen, N; Autio, V; Rökman, A; Matikainen, M P; Tammela, T L J; Schleutker, J

Book ID
109997844
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
97 KB
Volume
89
Category
Article
ISSN
0007-0920

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## Abstract Cell cycle checkpoint kinase 2 (CHEK2) is a transducer of cellular responses to DNA damage. The __CHEK2__ 1100delC has previously been shown to be a low‐penetrance breast cancer susceptibility allele. We have evaluated the role of another __CHEK2__ variant, I157T in the FHA domain of th