HPC2/ELAC2gene variants associated with incident prostate cancer
β Scribed by David Adler; Nimira Kanji; Kiril Trpkov; Gordon Fick; RhiannonM. Hughes
- Book ID
- 106251744
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 201 KB
- Volume
- 48
- Category
- Article
- ISSN
- 1435-232X
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## Abstract The __HPC2__/__ELAC2__ gene may be associated with hereditary/familial prostate cancer (PCa). Two common missense variants (Ser217Leu and Ala541Thr) have been reported in the gene. We performed mutational, allelotyping and expression analyses and a molecular epidemiological study to cla
## Abstract Three putative prostate cancerβsusceptibility genes, __RNASEL/HPC1__ at 1q24, __MSR1__ at 8p22, and __ELAC2/HPC2__ at 17p11, have recently been identified. Our objective was to investigate somatic mutations in these genes in sporadic prostate cancer. We analyzed 39 clinical prostate can