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Characterization of Substrates and Inhibitors for the In Vitro Assessment of Bcrp Mediated Drug–Drug Interactions

✍ Scribed by Uwe Muenster; Birgit Grieshop; Karsten Ickenroth; Mark Jean Gnoth

Publisher
Springer US
Year
2008
Tongue
English
Weight
149 KB
Volume
25
Category
Article
ISSN
0724-8741

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Although displacement from plasma protein binding (dPB) is usually of little clinical significance, it should be taken into account when interpreting changes in total plasma concentrations of drugs subject to metabolically based drug-drug interactions (mDDI). The aim of this study was to develop an