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Establishment of In Vitro P-Glycoprotein inhibition assay and its exclusion criteria to assess the risk of drug–drug interaction at the drug discovery stage

✍ Scribed by Hiroshi Sugimoto; Shin-ichi Matsumoto; Miho Tachibana; Shin-ichi Niwa; Hideki Hirabayashi; Nobuyuki Amano; Toshiya Moriwaki

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
273 KB
Volume
100
Category
Article
ISSN
0022-3549

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The absorptive (AQ) and secretory (SQ) quotients have been proposed as a novel experimental approach to quantify the modulation of intestinal absorption and secretion by P-glycoprotein (Pgp). Because these unidirectional assays inherently assess for the impact of Pgp, conclusions as to whether a com