An In Silico Transwell Device for the Study of Drug Transport and Drug–Drug Interactions
✍ Scribed by Lana X. Garmire; David G. Garmire; C. Anthony Hunt
- Publisher
- Springer US
- Year
- 2007
- Tongue
- English
- Weight
- 807 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0724-8741
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Drug‐induced phospholipidosis (PLD) is a side effect of the administration of cationic amphiphilic drugs (CADs). It is desirable to identify and screen compounds with the potential to induce PLD as early as possible in drug development. Recently, a number of in silico methods have been
Efficient transport of intact drug (solute) across the intestinal epithelium is typically a requirement for good oral activity. In general, the membrane permeability of a solute is a complex function of its size, lipophilicity, hydrogen bond potential, charge, and conformation. In conjunction with t