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An In Silico Transwell Device for the Study of Drug Transport and Drug–Drug Interactions

✍ Scribed by Lana X. Garmire; David G. Garmire; C. Anthony Hunt


Publisher
Springer US
Year
2007
Tongue
English
Weight
807 KB
Volume
24
Category
Article
ISSN
0724-8741

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📜 SIMILAR VOLUMES


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✍ Katarzyna R. Przybylak; Mark T. D. Cronin 📂 Article 📅 2011 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 241 KB

## Abstract Drug‐induced phospholipidosis (PLD) is a side effect of the administration of cationic amphiphilic drugs (CADs). It is desirable to identify and screen compounds with the potential to induce PLD as early as possible in drug development. Recently, a number of in silico methods have been

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✍ David A. Kloosterman; Jay T. Goodwin; Philip S. Burton; Robert A. Conradi; Brian 📂 Article 📅 2000 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 264 KB

Efficient transport of intact drug (solute) across the intestinal epithelium is typically a requirement for good oral activity. In general, the membrane permeability of a solute is a complex function of its size, lipophilicity, hydrogen bond potential, charge, and conformation. In conjunction with t