✦ LIBER ✦

Characterization of Combinatorial Peptide Libraries by Electrospray Ionization Fourier Transform Mass Spectrometry

✍ Scribed by Brian E. Winger; Joseph E. Campana

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 275 KB
Volume: 10
Category: Article
ISSN: 0951-4198
DOI: 10.1002/(sici)1097-0231(199611)10:14<1811::aid-rcm765>3.0.co;2-o

No coin nor oath required. For personal study only.

✦ Synopsis

The advantages of Fourier transform mass spectrometry (FTMS) are precision high mass accuracy measurements and the capability of high resolution, multistage mass spectrometry together with a number of other advanced features. These powerful facilities can be used to rapidly screen complex mixtures without the necessity of chromatographic separations. The example shown here illustrates the use of the high resolving power and accurate mass capabilities of FTMS for the rapid, direct analysis of a complex mixture, which had been ionized by direct infusion electrospray ionization.

Fipre2. High-resolution FTMS spectrum of the octapeptide mixture over the region containing the lysine, glutamine and glutamic acid isotopic species. The resolving power of WOO0 separates the isotopic species, which allows each of the three species and their "C isotopes to be distinguished.

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