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Changes of relaxation times T1 and T2 in rat tissues after biopsy and fixation

✍ Scribed by R.L. Kamman; K.G. Go; G.P. Stomp; C.E. Hulstaert; H.J.C. Berendsen

Publisher: Elsevier Science
Year: 1985
Tongue: English
Weight: 594 KB
Volume: 3
Category: Article
ISSN: 0730-725X
DOI: 10.1016/0730-725x(85)90353-4

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✦ Synopsis

NMR spectroscopical measurements of relaxation times were conducted on muscle, intestine, fatty tissue and cerebral cortex and white matter of the rat at various time intervals following removal of the tissue. It appeared that most tissues can be stored at 4°C up to 24 hours without noticeable effects on NMR relaxation parameters. Exceptions are the T2 of muscle and the T, and T2 of intestine, which tended to change in the first hour after biopsy. Relaxation parameters change considerably after fixation of the tissues. Therefore the effects of fixation have to be taken into account when carrying out NMR measurements on fixed tissues.

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