T1, T2 relaxation and magnetization transfer in tissue at 3T

✍ Scribed by Greg J. Stanisz; Ewa E. Odrobina; Joseph Pun; Michael Escaravage; Simon J. Graham; Michael J. Bronskill; R. Mark Henkelman

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 225 KB
• Volume: 54
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.20605

✦ Synopsis

Abstract

T~1~, T~2~, and magnetization transfer (MT) measurements were performed in vitro at 3 T and 37°C on a variety of tissues: mouse liver, muscle, and heart; rat spinal cord and kidney; bovine optic nerve, cartilage, and white and gray matter; and human blood. The MR parameters were compared to those at 1.5 T. As expected, the T~2~ relaxation time constants and quantitative MT parameters (MT exchange rate, R, macromolecular pool fraction, M~0B~, and macromolecular T~2~ relaxation time, T~2B~) at 3 T were similar to those at 1.5 T. The T~1~ relaxation time values, however, for all measured tissues increased significantly with field strength. Consequently, the phenomenological MT parameter, magnetization transfer ratio, MTR, was lower by approximately 2 to 10%. Collectively, these results provide a useful reference for optimization of pulse sequence parameters for MRI at 3 T. Magn Reson Med, 2005. © 2005 Wiley‐Liss, Inc.