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Changes of intracellular sodium T2 relaxation times during ischemia and reperfusion in isolated rat hearts

✍ Scribed by Jan G. van Emous; Cees J. A. van Echteld

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
547 KB
Volume
40
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

The effect of ischemia and reperfusion on transverse relax ation (T~2~) of intracellular Na^+^ (Na^+^~i~) was measured with 5‐min time resolution in isolated rat hearts. Na~i~ T~2~ relaxation was biexponential with 28 Β± 7% fast (T~2f~)and 72 Β± 7% slow (T~2s~) decay. This ratio was constant throughout the protocol. Dur ing 20 min of ischemia, Na~i~ T~2s~ increased from 18.9 Β± 2.7 ms to 26.4 Β± 1.1 ms (P < 0.001), whereas T~2f~ did not change significantly (3.1 Β± 1.8 versus 2.3 Β± 1.6 ms during control), and Na+~i~ increased from 9.0 Β± 1.0 to 19.5 Β± 1.0 mmol/liter (P < 0.001). T~2s~ and Na^+^~i~ declined again during reperfusion. Changes in T~2s~ relaxation correlated significantly (r = 0.73, P < 0.001) with the time course of Na^+^~i~.

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