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Cerebrospinal fluid JC virus antibody index for diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy

✍ Scribed by Warnke, Clemens; von Geldern, Gloria; Markwerth, Philipp; Dehmel, Thomas; Hoepner, Robert; Gold, Ralf; Pawlita, Michael; Kümpfel, Tania; Mäurer, Mathias; Stangel, Martin; Wegner, Florian; Hohlfeld, Reinhard; Straeten, Vera; Limmroth, Volker; Weber, Thomas; Hermsen, Derik; Kleinschnitz, Christoph; Hartung, Hans-Peter; Wattjes, Mike P.; Svenningson, Anders; Major, Eugene; Olsson, Tomas; Kieseier, Bernd C.; Adams, Ortwin


Book ID
121854597
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
296 KB
Volume
76
Category
Article
ISSN
0364-5134

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Progressive multifocal leukoencephalopathy (PML) is a lytic infection of oligodendrocytes by the human papovavirus JC. Patients with defects in cell-mediated immunity are at risk for active disease: a usually lethal demyelination of the brain. PML develops in at least 4% of patients with the acquire