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JC virus load in cerebrospinal fluid and transcriptional control region rearrangements may predict the clinical course of progressive multifocal leukoencephalopathy

✍ Scribed by Serena Delbue; Francesca Elia; Camilla Carloni; Eleonora Tavazzi; Enrico Marchioni; Silvia Carluccio; Lucia Signorini; Stefano Novati; Renato Maserati; Pasquale Ferrante

Book ID: 112120750
Publisher: John Wiley and Sons
Year: 2012
Tongue: English
Weight: 323 KB
Volume: 227
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.24051

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## Abstract The human polyomavirus JC (JCV) is the causative agent of progressive multifocal leukoencephalopathy (PML), a fatal demyelinating disease of the central nervous system (CNS). JCV has a hyper‐variable non‐coding transcriptional control region (TCR), which contains the origin of replicati