𝔖 Bobbio Scriptorium
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Cell-mediated responses to tumour xenografts in mice

✍ Scribed by Elizabeth Simpson; P. C. L. Beverley

Publisher
John Wiley and Sons
Year
1972
Tongue
French
Weight
416 KB
Volume
9
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

A micro‐cytotoxic assay has been used to follow the course of the cell‐mediated response to a tumour xenograft in normal and ALS‐treated mice. In normal mice a peak response was seen at day 10 in both lymph nodes and spleen. Further peaks of cytotoxic activity were seen at days 18 and 42 in the spleen. In ALS‐treated mice, in which the tumour grew progressively, the response was slightly delayed in both lymph nodes and spleen. Subsequently 10 out of 12 mice bearing progressively growing tumours, tested at times up to 83 days after tumour grafting, showed immunity in either lymph nodes, spleen or both.

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