Immune responses in mice to tumour challenge after immunization with newcastle disease virus-infected or X-irradiated tumour cells or cell fractions
✍ Scribed by P. C. L. Beverley; R. M. Lowenthal; D. A. J. Tyrrell
- Publisher
- John Wiley and Sons
- Year
- 1973
- Tongue
- French
- Weight
- 803 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
Cells of the transplantable ascites tumour sarcoma 37 (S37) have been infected in vitro with Newcastle disease virus (NDV). Infected cells, a virus‐containing fraction of such cells, and X‐irradiated S37 cells have been found to immunize mice against subsequent tumour challenge. Anti‐lymphocyte serum and anti‐theta serum interfered with this immune response. The level of humoral anti‐tumour antibody did not correlate with immunity. Preimmunization with homologous virus (NDV) prior to inoculation with a virus‐containing tumour cell fraction did not in this system enhance the immune response against tumour challenge. The implications of these findings are discussed. Caution is advocated in applying the results of experiments with such animal tumour virus models to the human clinical situation.