𝔖 Bobbio Scriptorium
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Cell-mediated immunity to varicella-zoster virus infection in strain 2 guinea pigs

✍ Scribed by Laura Jenski; Dr. Martin G. Myers

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
511 KB
Volume
23
Category
Article
ISSN
0146-6615

No coin nor oath required. For personal study only.

✦ Synopsis

Young adult male strain 2 guinea pigs were inoculated intramuscularly with varicellazoster virus (VZV) cultured in fetal guinea pig tissue cultures. Lymphocyte proliferation and interleukin 2 secretion in response to viral antigen challenge in vitro were measured at weekly intervals for 2 months and periodically thereafter. VZV-specific immunity was apparent 2 weeks after infection, peaking after 2 weeks (lymphoproliferation) or 1-2 months (interleukin 2 secretion). Diminished but significant anamnestic responses were detected as late as 30 months after infection.

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