𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Long-term T-cell-mediated immunity to Epstein-Barr virus in man. II. Components necessary for regression in virus-infected leukocyte cultures

✍ Scribed by A. B. Rickinson; D. J. Moss; J. H. Pope

Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
744 KB
Volume
23
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Regression of EB‐virus‐induced transformation occurs exclusively in cultures of leukocytes from seropositive donors. Studies have shown that the strength of regression could be assayed in terms of the proportion of T cells which must be added to the autologous EB virus‐infected T‐cell‐depleted population in order to establish regression in the culture. The in vitro regression phenomenon was strongly T‐cell‐dependent but did not require the presence of either monocytes or, as a potential antigenic stimulus, the residual viral envelope material on the surface of virus‐infected B cells. The T‐cell‐depleted population from seropositive donors sometimes transformed (7/60 cultures) without the experimental addition of virus. Regression appeared to be independent of cytotoxic mechanisms involving anti‐viral antibodies and not to be mediated by soluble factors released into culture medium.

📜 SIMILAR VOLUMES

Long-term T-cell-mediated immunity to Ep
Long-term T-cell-mediated immunity to Epstein-Barr virus in man. III. Activation of cytotoxic T cells in virus-infected leukocyte cultures
✍ D. J. Moss; A. B. Rickinson; J. H. Pope 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 French ⚖ 819 KB

## Abstract Experiments have been conducted to determine the role played by immune T cells in the regression of EB‐virus‐induced transformation which is exclusively seen in leukocyte cultures from seropositive donors. Kinetic studies suggest that, In virus‐infected cultures from such donors, a popu

Long-term T-cell-mediated immunity to ep
Long-term T-cell-mediated immunity to epstein-barr virus in man. I. Complete regression of virus-induced transformation in cultures of seropositive donor leukocytes
✍ D. J. Moss; A. B. Rickinson; J. H. Pope 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 French ⚖ 782 KB

## Abstract Peripheral blood mononuclear cells from donors of known serological status with respect to EB virus were exposed to the virus __in vitro__ and then cultured at various cell concentrations. All cultures from nine seronegative adult and 12 foetal donors gave rise to cell lines following s

Studies on long-term T-cell-mediated imm
Studies on long-term T-cell-mediated immunity to epstein-barr virus in immunosuppressed renal allograft recipients
✍ D. H. Crawford; J. M. B. Edwards; P. Sweny; A. V. Hoffbrand; G. Janossy 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 448 KB 👁 1 views

## Abstract Peripheral blood lymphocytes from normal seropositive donors and renal transplant recipients on various immunosuppressive regimens have been tested for their ability to mount a cytotoxic response when cultured with autologous EB virus‐infected B cells and thereby to cause regression of

Long-term T-cell-mediated immunity to ep
Long-term T-cell-mediated immunity to epstein-barr virus in man. IV. Development of T-cell memory in convalescent infectious mononucleosis patients
✍ A. B. Rlckinson; D. J. Moss; J. H. Pope; N. Ahlberg 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 French ⚖ 650 KB

## Abstract Under appropriate culture conditions, EB virus infection of lymphocytes from seropositive donors leads to regression of transformation, and this was shown previously to be due to activation in a secondary immune response of T lymphocytes inhibitory for the autologous lymphoblastoid cell