Immunological maturation in cell-mediated immunity: progressive increase with time after sensitization in the ability of guinea pig peritoneal cells to discriminate between cross-reacting determinants
✍ Scribed by Liisa Jokipii; A. M. M. Jokipii; S. Leskowitz; T. U. Kosunen
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- English
- Weight
- 351 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0014-2980
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✦ Synopsis
Abstract
Guinea pigs were sensitized with the azobenzenearsonate (ABA) conjugates of the N‐acetyl derivatives of L‐tyrosine, L‐histidine and L‐tryptophan in complete Freund's adjuvant. After 4, 9 or 14 weeks, pertioneal cell migration inhibition was tested with each conjugate separately. The ABA‐specific reactivity was strongest at four weeks, but at that time there was no detectable immunological specificity beyond the ABA moiety. The ability to discriminate between the homologous and heterologous conjugates appeared between 4 and 9 weeks, and was also found at 14 weeks. Increasing fine specificity discrimination between cross‐reacting immunogenic determinants was interpreted as increasing average affinity of the recognition structures involved in peritoneal cell migration inhibition, i.e. the recognition structures of thymus‐dependent lymphocytes.