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Cell-mediated destruction of rous sarcomas in Japanese quails

✍ Scribed by Masanori Hayami; Ingegerd Hellström; Karl Erik Hellström; Kazuya Yamanouchi

Publisher
John Wiley and Sons
Year
1972
Tongue
French
Weight
698 KB
Volume
10
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

A microcytotoxicity test was used to search for cell‐mediated destruction of sarcomas, induced in Japanese quails by the Schmidt‐Ruppin strain of the Rous sarcoma virus (SR‐RSV).

Spleen cells from quails whose sarcomas had regressed (regressors) were cytotoxic to cultivated Rous sarcoma cells as were, to a lesser extent, regressor thymus cells, while no cytotoxic effect was seen with bursa cells. Autochthonous and allogeneic lymphoid cells from regressors were equally cytotoxic. No cytotoxic effect was seen, on the other hand, with lymphoid cells from quails with growing Rous sarcomas (progressors).

Surgical bursectomy on the day of hatching, which depressed the formation of antibody production to sheep red‐blood cells, led to a higher cytotoxic effect of regressor spleen cells than was seen with cells from non‐bursectomized quails. Spleen cells from thymectomized birds which showed delayed skin graft rejection and had progressively growing rumors were not cytotoxic.

Admixture of progressor spleen cells decreased the cytotoxic activity of normal regressor spleen cells unless the regressors had been bursectomized.

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