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A rapid destructive effect of the Schmidt-Ruppin strain of rous sarcoma virus on transformed rat cell lines

✍ Scribed by Carol L. Reinisch; Frederik B. Bang

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
570 KB
Volume
11
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

A cytopathic effect was induced by the Schmidt‐Ruppin strain of Rous sarcoma virus (RSV‐SR) in five of nine rat tumor cell lines tested in vitro. The cells showed irreversible cytopathic change as early as 24‐48 h after infection. Of the leukemogenic and tumorigenic viral agents tested, only RSV‐SR induced the rapid Rous cytopathic effect. Virus was recovered 8 days after inoculation of the tumor cell lines XC and M41. The effect was neutralized by specific anti‐RSV‐SR antiserum. Correlation between oncogenicity of the rat tumor lines in the syngeneic host and their susceptibility to RSV‐SR was incomplete.

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## Abstract In order to investigate a possible correlation beween __in vitro__ transformation and tumorigenicity __in ovo__, a new temperature‐sensitive class T mutant of Rous Sarcoma Virus was isolated with a lower (39·5C) restrictive temperature for morphological transformation. This lower restri