Progress is being made in determining how cytotoxic cells are activated, the way the lethal hit is delivered and the subsequent events in the target cell. Several factors cloud the issue, including the heterogeneity of cytotoxic cells, differences between fresh cells and cell lines, and the possibil
Cell-mediated cytotoxicity
โ Scribed by Peter C. Doherty
- Book ID
- 119064404
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 797 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0092-8674
No coin nor oath required. For personal study only.
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There are two competing theories to explain the mechanism(s) by which cytolytic T lymphocytes kill target cells: granule exocytosis of a pore-forming protein, and contact-induced internal disintegration. Accumulated evidence supports alternative pathways in lymphocytoxicity, possibly reflecting dist
## Natural cell-mediated cytotoxicity has been shown to be age-dependent in both rats and mice. The present study was undertaken to study age-related levels of natural cytotoxicity in humans. Mononuclear peripheral blood cells from over 200 normal volunteers were co-incubated with 51Cr-labeled K-5