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Cell cycle inhibitor p21/ WAF1/ CIP1 as a cofactor of MITF expression in melanoma cells

✍ Scribed by Blanka Šestáková; Lubica Ondrušová; Jiri Vachtenheim

Book ID
111756889
Publisher
Wiley (Blackwell Publishing)
Year
2010
Tongue
English
Weight
494 KB
Volume
23
Category
Article
ISSN
1755-1471

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## Abstract Transforming growth factor‐β (TGF‐β) inhibits epithelial cell growth, in part via transcriptional induction of the cell cycle inhibitor p21^WAF1/Cip1^ (p21). We show that bone morphogenetic protein (BMP)‐7 induces higher p21 expression than TGF‐β1 in various epithelial cells. Despite th