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HIV-1 Vpr Activates Cell Cycle Inhibitor p21/Waf1/Cip1: A Potential Mechanism of G2/M Cell Cycle Arrest

✍ Scribed by Iqbal H. Chowdhury; Xiao-Fan Wang; Nathaniel R. Landau; Merlin L. Robb; Victoria R. Polonis; Deborah L. Birx; Jerome H. Kim

Book ID
112274355
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
154 KB
Volume
305
Category
Article
ISSN
0042-6822

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## Abstract Transforming growth factor‐β (TGF‐β) inhibits epithelial cell growth, in part via transcriptional induction of the cell cycle inhibitor p21^WAF1/Cip1^ (p21). We show that bone morphogenetic protein (BMP)‐7 induces higher p21 expression than TGF‐β1 in various epithelial cells. Despite th