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Celecoxib, a cyclooxygenase-2 inhibitor, potentiates the chemotherapic effect of vinorelbine in the medullary thyroid cancer TT cell line

✍ Scribed by A. Vivaldi; R. Ciampi; A. Tacito; E. Molinaro; L. Agate; V. Bottici; A. Pinchera; P. Collecchi; R. Elisei


Book ID
113796394
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
450 KB
Volume
355
Category
Article
ISSN
0303-7207

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## Abstract ## Background. The protooncogenes Ets‐1 and Ets‐2 are involved in carcinogenesis of different tumors. Nimesulide, a selective cyclooxygenase‐2 (COX‐2) inhibitor, has antiproliferative effects on tumor cells. The question arises whether nimesulide influences Ets‐1 and Ets‐2 synthesis in