CDKN2A/p16 in ependymomas
✍ Scribed by Simona Bortolotto; Loredana Chiadò-Piat; Paola Cavalla; Ivana Bosone; Alessandro Mauro; Davide Schiffer
- Book ID
- 110314083
- Publisher
- Springer US
- Year
- 2001
- Tongue
- English
- Weight
- 580 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0167-594X
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To elucidate the possibility of the existence of multiple tumor suppressor genes on chromosome arm 9p, we performed genetic and epigenetic analyses of the CDKN2A/p16/MTS1 and CDKN2B/p15/MTS2 genes as well as homozygous deletion mapping of 9p in human lung carcinoma. To avoid overlooking genetic alte
The cell cycle is composed of a series of steps that can be negatively or positively regulated by various factors. A group of low-molecular-weight proteins have recently been identified that specifically inhibit the function of cyclin-dependent kinases in mammalian cells. Inactivation of the CDKNZA