CDKN2/p16 Predicts Survival in Oligodendrogliomas: Comparison with Astrocytomas
✍ Scribed by Helena Miettinen; Juha Kononen; Pauli Sallinen; Hannu Alho; Pauli Helen; Heikki Helin; Hannu Kalimo; Leo Paljärvi; Jorma Isola; Hannu Haapasalo
- Book ID
- 110232903
- Publisher
- Springer US
- Year
- 1999
- Tongue
- English
- Weight
- 81 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0167-594X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## BACKGROUND. Alterations of the suppressor genes, such as the retinoblastoma (RB), p53, pl6(CDKN2), and p15 genes, have been reported in human gliomas. These genes have been suggested as the cell cycle regulatory genes at the G,-S checkpoint.
Inherited mutations affecting the INK4a/ARF locus (CDKN2A) are associated with melanoma susceptibility in 40% of multiple case melanoma families. Over 60 different germline INK4a/ARF mutations have been detected in more than 190 families worldwide. The majority of these alterations are missense muta