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Catalytic Enantioselective Synthesis of Chiral γ-Butyrolactones

✍ Scribed by Yanagisawa, Akira; Kushihara, Naoyuki; Yoshida, Kazuhiro


Book ID
125439949
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
695 KB
Volume
13
Category
Article
ISSN
1523-7060

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Combination of Pd(OCOCF 3 ) 2 and (M,S,S)-iPr-SPRIX ligand promoted the intramolecular cyclization of 2-alkynoates very effectively to form a-methylene-g-butyrolactones in good yields with up to 92% ee.