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Enantioselective synthesis of α-methylene-γ-butyrolactones using chiral Pd(II)-SPRIX catalyst

✍ Scribed by Chinnasamy Muthiah; Midori A. Arai; Toshio Shinohara; Takayoshi Arai; Shinobu Takizawa; Hiroaki Sasai


Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
186 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis


Combination of Pd(OCOCF 3 ) 2 and (M,S,S)-iPr-SPRIX ligand promoted the intramolecular cyclization of 2-alkynoates very effectively to form a-methylene-g-butyrolactones in good yields with up to 92% ee.


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