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Carbonic Anhydrase Inhibitors: X-ray and Molecular Modeling Study for the Interaction of a Fluorescent Antitumor Sulfonamide with Isozyme II and IX

✍ Scribed by Alterio, Vincenzo; Vitale, Rosa Maria; Monti, Simona Maria; Pedone, Carlo; Scozzafava, Andrea; Cecchi, Alessandro; De Simone, Giuseppina; Supuran, Claudiu T.


Book ID
125480131
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
490 KB
Volume
128
Category
Article
ISSN
0002-7863

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Carbonic Anhydrase Activators: X-ray Cry
✍ Briganti, Fabrizio; Mangani, Stefano; Orioli, Pierluigi; Scozzafava, Andrea; Ver πŸ“‚ Article πŸ“… 1997 πŸ› American Chemical Society 🌐 English βš– 219 KB

The interaction of native and Co(II)-substituted isozymes I and II of carbonic anhydrase (CA) with histamine, a well-known activator, was investigated kinetically, spectroscopically, and X-ray crystallographically. This activator is of the noncompetitive type with 4-nitrophenyl acetate and CO 2 as s