Carbonic Anhydrase Activators: X-ray Cry
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Briganti, Fabrizio; Mangani, Stefano; Orioli, Pierluigi; Scozzafava, Andrea; Ver
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Article
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1997
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American Chemical Society
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English
⚖ 219 KB
The interaction of native and Co(II)-substituted isozymes I and II of carbonic anhydrase (CA) with histamine, a well-known activator, was investigated kinetically, spectroscopically, and X-ray crystallographically. This activator is of the noncompetitive type with 4-nitrophenyl acetate and CO 2 as s