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Carbonic Anhydrase Activators: X-ray Crystallographic and Spectroscopic Investigations for the Interaction of Isozymes I and II with Histamine †,‡

✍ Scribed by Briganti, Fabrizio; Mangani, Stefano; Orioli, Pierluigi; Scozzafava, Andrea; Vernaglione, Guido; Supuran, Claudiu T.


Book ID
126404872
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
219 KB
Volume
36
Category
Article
ISSN
0006-2960

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Carbonic Anhydrase Activators: X-ray Cry
✍ Briganti, Fabrizio; Mangani, Stefano; Orioli, Pierluigi; Scozzafava, Andrea; Ver 📂 Article 📅 1997 🏛 American Chemical Society 🌐 English ⚖ 219 KB

The interaction of native and Co(II)-substituted isozymes I and II of carbonic anhydrase (CA) with histamine, a well-known activator, was investigated kinetically, spectroscopically, and X-ray crystallographically. This activator is of the noncompetitive type with 4-nitrophenyl acetate and CO 2 as s